Structure and Engineering of Francisella novicida Cas9

The RNA-guided endonuclease Cas9 cleaves double-stranded DNA targets complementary to the guide RNA, and has been applied to programmable genome editing. Cas9-mediated cleavage requires a protospacer adjacent motif (PAM) juxtaposed with the DNA target sequence, thus constricting the range of targeta...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Hirano, Hisato, Gootenberg, Jonathan S., Horii, Takuro, Abudayyeh, Omar O., Kimura, Mika, Hsu, Patrick D., Nakane, Takanori, Ishitani, Ryuichiro, Hatada, Izuho, Zhang, Feng, Nishimasu, Hiroshi, Nureki, Osamu
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899972/
https://ncbi.nlm.nih.gov/pubmed/26875867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.039
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