Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule

Human ribonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool, and is an established cancer target. Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR. These drugs have a poor therapeuti...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ahmad, Md. Faiz, Alam, Intekhab, Huff, Sarah E., Pink, John, Flanagan, Sheryl A., Shewach, Donna, Misko, Tessianna A., Oleinick, Nancy L., Harte, William E., Viswanathan, Rajesh, Harris, Michael E., Dealwis, Chris Godfrey
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547592/
https://ncbi.nlm.nih.gov/pubmed/28716944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620220114
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