Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators

Ribonucleotide reductase (RR) catalyzes the rate-limiting step of dNTP synthesis and is an established cancer target. Drugs targeting RR are mainly nucleoside in nature. In this study, we sought to identify non-nucleoside small-molecule inhibitors of RR. Using virtual screening, binding affinity, in...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Med Chem
Autori principali: Ahmad, Md. Faiz, Huff, Sarah E., Pink, John, Alam, Intekhab, Zhang, Andrew, Perry, Kay, Harris, Michael E., Misko, Tessianna, Porwal, Suheel K., Oleinick, Nancy L., Miyagi, Masaru, Viswanathan, Rajesh, Dealwis, Chris Godfrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751996/
https://ncbi.nlm.nih.gov/pubmed/26488902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00929
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi