Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators

Ribonucleotide reductase (RR) catalyzes the rate-limiting step of dNTP synthesis and is an established cancer target. Drugs targeting RR are mainly nucleoside in nature. In this study, we sought to identify non-nucleoside small-molecule inhibitors of RR. Using virtual screening, binding affinity, in...

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Publicado en:J Med Chem
Main Authors: Ahmad, Md. Faiz, Huff, Sarah E., Pink, John, Alam, Intekhab, Zhang, Andrew, Perry, Kay, Harris, Michael E., Misko, Tessianna, Porwal, Suheel K., Oleinick, Nancy L., Miyagi, Masaru, Viswanathan, Rajesh, Dealwis, Chris Godfrey
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751996/
https://ncbi.nlm.nih.gov/pubmed/26488902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00929
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