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Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH) that binds reversi...
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| 出版年: | J Enzyme Inhib Med Chem |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6328008/ https://ncbi.nlm.nih.gov/pubmed/30734609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1545226 |
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