Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner

Currently several combination treatments of mTor- and Ras-pathway inhibitors are being tested in cancer therapy. While multiple feedback loops render these central signaling pathways robust, they complicate drug targeting. Here, we describe a novel H-ras specific feedback, which leads to an inadvert...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Posada, Itziar M.D., Lectez, Benoit, Sharma, Mukund, Oetken-Lindholm, Christina, Yetukuri, Laxman, Zhou, Yong, Aittokallio, Tero, Abankwa, Daniel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2017
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546501/
https://ncbi.nlm.nih.gov/pubmed/28562352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17819
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