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Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1
As a major growth factor transducer, Ras is an upstream activator of mTORC1, which further integrates nutrient and energy inputs. To ensure a contextual coupling of cell division via Ras/MAPK-signalling and growth via mTORC1-signalling, feedback loops from one pathway back to the other are required....
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567141/ https://ncbi.nlm.nih.gov/pubmed/28827765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09387-8 |
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