ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold

Ras-induced senescence mediated through ASPP2 represents a barrier to tumour formation. It is initiated by ASPP2’s interaction with Ras at the plasma membrane, which stimulates the Raf/MEK/ERK signaling cascade. Ras to Raf signalling requires Ras to be organized in nanoscale signalling complexes, ca...

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Bibliographic Details
Published in:PLoS One
Main Authors: Posada, Itziar M. D., Serulla, Marc, Zhou, Yong, Oetken-Lindholm, Christina, Abankwa, Daniel, Lectez, Benoît
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954646/
https://ncbi.nlm.nih.gov/pubmed/27437940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159677
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