Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. Here, we show that several cancer-associated mutatio...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Šolman, Maja, Ligabue, Alessio, Blaževitš, Olga, Jaiswal, Alok, Zhou, Yong, Liang, Hong, Lectez, Benoit, Kopra, Kari, Guzmán, Camilo, Härmä, Harri, Hancock, John F, Aittokallio, Tero, Abankwa, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563131/
https://ncbi.nlm.nih.gov/pubmed/26274561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08905
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