Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. Here, we show that several cancer-associated mutatio...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Šolman, Maja, Ligabue, Alessio, Blaževitš, Olga, Jaiswal, Alok, Zhou, Yong, Liang, Hong, Lectez, Benoit, Kopra, Kari, Guzmán, Camilo, Härmä, Harri, Hancock, John F, Aittokallio, Tero, Abankwa, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563131/
https://ncbi.nlm.nih.gov/pubmed/26274561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08905
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