Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering

Galectin-1 (Gal-1) dimers crosslink carbohydrates on cell surface receptors. Carbohydrate-derived inhibitors have been developed for cancer treatment. Intracellularly, Gal-1 was suggested to interact with the farnesylated C-terminus of Ras thus specifically stabilizing GTP-H-ras nanoscale signalling...

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Publicado en:Sci Rep
Autores principales: Blaževitš, Olga, Mideksa, Yonatan G., Šolman, Maja, Ligabue, Alessio, Ariotti, Nicholas, Nakhaeizadeh, Hossein, Fansa, Eyad K., Papageorgiou, Anastassios C., Wittinghofer, Alfred, Ahmadian, Mohammad R., Abankwa, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834570/
https://ncbi.nlm.nih.gov/pubmed/27087647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24165
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