Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. Here, we show that several cancer-associated mutatio...

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Publicat a:eLife
Autors principals: Šolman, Maja, Ligabue, Alessio, Blaževitš, Olga, Jaiswal, Alok, Zhou, Yong, Liang, Hong, Lectez, Benoit, Kopra, Kari, Guzmán, Camilo, Härmä, Harri, Hancock, John F, Aittokallio, Tero, Abankwa, Daniel
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Biophysics and Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563131/
https://ncbi.nlm.nih.gov/pubmed/26274561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08905
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