SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1

There is a growing appreciation for a fundamental connection between lipid metabolism and the immune response. Macrophage phagocytosis is a signature innate immune response to pathogen exposure, and cytoplasmic membrane expansion is required to engulf the phagocytic target. The sterol regulatory ele...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lee, Jae-Ho, Phelan, Peter, Shin, Minsang, Oh, Byung-Chul, Han, Xianlin, Im, Seung-Soon, Osborne, Timothy F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310840/
https://ncbi.nlm.nih.gov/pubmed/30530672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813458115
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