SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

The synthesis of lipid and sterol species through de novo lipogenesis (DNL) is regulated by 2 functionally overlapping but distinct transcription factors: the SREBPs and carbohydrate response element–binding protein (ChREBP). ChREBP is considered to be the dominant regulator of DNL in adipose tissue...

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Publicat a:JCI Insight
Autors principals: Crewe, Clair, Zhu, Yi, Paschoal, Vivian A., Joffin, Nolwenn, Ghaben, Alexandra L., Gordillo, Ruth, Oh, Da Young, Liang, Guosheng, Horton, Jay D., Scherer, Philipp E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693888/
https://ncbi.nlm.nih.gov/pubmed/31310592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129397
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