Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

Through unknown mechanisms, insulin activates the sterol regulatory element-binding protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that this induction is dependent on the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). To further define the role of mTORC1 in...

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Detalhes bibliográficos
Main Authors: Yecies, Jessica L., Zhang, Hui H., Menon, Suchithra, Liu, Sihao, Yecies, Derek, Lipovsky, Alex I., Gorgun, Cem, Kwiatkowski, David J., Hotamisligil, Gökhan S., Lee, Chih-Hao, Manning, Brendan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652544/
https://ncbi.nlm.nih.gov/pubmed/21723501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.06.002
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