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Coordinated regulation of protein synthesis and degradation by mTORC1

Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and tissue homeostasis. The mechanistic target of rapamycin complex 1 (mTORC1) promotes nutrient-consuming anabolic processes, such as protein synthesis(1). Here, we show that accompanying an increase in protein...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Zhang, Yinan, Nicholatos, Justin, Dreier, John R., Ricoult, Stéphane J. H., Widenmaier, Scott B., Hotamisligil, Gökhan S., Kwiatkowski, David J., Manning, Brendan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402229/
https://ncbi.nlm.nih.gov/pubmed/25043031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13492
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