SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1

There is a growing appreciation for a fundamental connection between lipid metabolism and the immune response. Macrophage phagocytosis is a signature innate immune response to pathogen exposure, and cytoplasmic membrane expansion is required to engulf the phagocytic target. The sterol regulatory ele...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lee, Jae-Ho, Phelan, Peter, Shin, Minsang, Oh, Byung-Chul, Han, Xianlin, Im, Seung-Soon, Osborne, Timothy F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310840/
https://ncbi.nlm.nih.gov/pubmed/30530672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813458115
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