Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

The coincidences between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are so compelling that it is attractive to speculate that diabetic conditions might aggravate AD pathologies by calcium dysfunction, although the understanding of the molecular mechanisms involved remains elusive....

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Shuai, Chai, Rui, Yang, Ying-Ying, Guo, Shi-Qi, Wang, Shan, Guo, Tian, Xu, Shuang-Feng, Zhang, Yan-Hui, Wang, Zhan-You, Guo, Chuang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546429/
https://ncbi.nlm.nih.gov/pubmed/28467789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17116
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