Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

Compelling evidence has indicated that dysregulated glucose metabolism links Alzheimer’s disease (AD) and diabetes mellitus (DM) via glucose metabolic products. Nevertheless, because of the lack of appropriate animal models, whether chronic hyperglycemia worsens AD pathologies in vivo remains to be...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Guo, Chuang, Zhang, Shuai, Li, Jia-Yi, Ding, Chen, Yang, Zhao-Hui, Chai, Rui, Wang, Xu, Wang, Zhan-You
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942607/
https://ncbi.nlm.nih.gov/pubmed/27406855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29396
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