Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

Compelling evidence has indicated that dysregulated glucose metabolism links Alzheimer’s disease (AD) and diabetes mellitus (DM) via glucose metabolic products. Nevertheless, because of the lack of appropriate animal models, whether chronic hyperglycemia worsens AD pathologies in vivo remains to be...

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Pubblicato in:Sci Rep
Autori principali: Guo, Chuang, Zhang, Shuai, Li, Jia-Yi, Ding, Chen, Yang, Zhao-Hui, Chai, Rui, Wang, Xu, Wang, Zhan-You
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942607/
https://ncbi.nlm.nih.gov/pubmed/27406855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29396
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