Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice

Aim. Models combining diabetes and atherosclerosis are important in evaluating the cardiovascular (CV) effects and safety of antidiabetes drugs in the development of treatments targeting CV complications. Our aim was to evaluate if crossing the heterozygous glucokinase knockout mouse (GK(+/−)) and h...

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Detalhes bibliográficos
Publicado no:J Diabetes Res
Main Authors: Adingupu, Damilola D., Heinonen, Suvi E., Andréasson, Anne-Christine, Brusberg, Mikael, Ahnmark, Andrea, Behrendt, Margareta, Leighton, Brendan, Jönsson-Rylander, Ann-Cathrine
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059602/
https://ncbi.nlm.nih.gov/pubmed/27774459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/8630961
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