Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

The coincidences between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are so compelling that it is attractive to speculate that diabetic conditions might aggravate AD pathologies by calcium dysfunction, although the understanding of the molecular mechanisms involved remains elusive....

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Udgivet i:Oncotarget
Main Authors: Zhang, Shuai, Chai, Rui, Yang, Ying-Ying, Guo, Shi-Qi, Wang, Shan, Guo, Tian, Xu, Shuang-Feng, Zhang, Yan-Hui, Wang, Zhan-You, Guo, Chuang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546429/
https://ncbi.nlm.nih.gov/pubmed/28467789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17116
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