High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

Obesity is linked to increased risk for and severity of Alzheimer’s disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We recently showed that non-flowing capillaries, caused by adhered neutrophils, contribute to CBF reduction in mouse model...

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Publicado en:Sci Rep
Main Authors: Bracko, Oliver, Vinarcsik, Lindsay K., Cruz Hernández, Jean C., Ruiz-Uribe, Nancy E., Haft-Javaherian, Mohammad, Falkenhain, Kaja, Ramanauskaite, Egle M., Ali, Muhammad, Mohapatra, Aditi, Swallow, Madisen A., Njiru, Brendah N., Muse, Victorine, Michelucci, Pietro E., Nishimura, Nozomi, Schaffer, Chris B.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303150/
https://ncbi.nlm.nih.gov/pubmed/32555372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65908-y
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