High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

Obesity is linked to increased risk for and severity of Alzheimer’s disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We recently showed that non-flowing capillaries, caused by adhered neutrophils, contribute to CBF reduction in mouse model...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Bracko, Oliver, Vinarcsik, Lindsay K., Cruz Hernández, Jean C., Ruiz-Uribe, Nancy E., Haft-Javaherian, Mohammad, Falkenhain, Kaja, Ramanauskaite, Egle M., Ali, Muhammad, Mohapatra, Aditi, Swallow, Madisen A., Njiru, Brendah N., Muse, Victorine, Michelucci, Pietro E., Nishimura, Nozomi, Schaffer, Chris B.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303150/
https://ncbi.nlm.nih.gov/pubmed/32555372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65908-y
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