Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis

Although translational research into autosomal dominant polycystic kidney disease (ADPKD) and its pathogenesis has made considerable progress, there is presently lack of standardized animal model for preclinical trials. In this study, we developed an orthologous mouse model of human ADPKD by cross‐m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Cell Mol Med
Päätekijät: Li, Ao, Fan, Song, Xu, Yuchen, Meng, Jialin, Shen, Xufeng, Mao, Jun, Zhang, Li, Zhang, Xiansheng, Moeckel, Gilbert, Wu, Dianqing, Wu, Guanqing, Liang, Chaozhao
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543471/
https://ncbi.nlm.nih.gov/pubmed/28244683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13091
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