Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously showed that a lack of the PKD2 gene product, PC2, increases β-catenin signaling in mouse embryonic fibroblasts, kidney renal...

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Pubblicato in:JCI Insight
Autori principali: Li, Ao, Xu, Yuchen, Fan, Song, Meng, Jialin, Shen, Xufeng, Xiao, Qian, Li, Yuan, Zhang, Li, Zhang, Xiansheng, Wu, Guanqing, Liang, Chaozhao, Wu, Dianqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922276/
https://ncbi.nlm.nih.gov/pubmed/29515026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95874
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