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Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD
Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously showed that a lack of the PKD2 gene product, PC2, increases β-catenin signaling in mouse embryonic fibroblasts, kidney renal...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5922276/ https://ncbi.nlm.nih.gov/pubmed/29515026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95874 |
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