mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, we identify the mammalian target of rapamycin compl...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Feng, Daorong, Youn, Dou Yeon, Zhao, Xiaoping, Gao, Yanguang, Quinn, William J., Xiaoli, Alus M., Sun, Yan, Birnbaum, Morris J., Pessin, Jeffrey E., Yang, Fajun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456374/
https://ncbi.nlm.nih.gov/pubmed/26042770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126240
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