mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, we identify the mammalian target of rapamycin compl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Feng, Daorong, Youn, Dou Yeon, Zhao, Xiaoping, Gao, Yanguang, Quinn, William J., Xiaoli, Alus M., Sun, Yan, Birnbaum, Morris J., Pessin, Jeffrey E., Yang, Fajun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456374/
https://ncbi.nlm.nih.gov/pubmed/26042770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126240
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