mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, we identify the mammalian target of rapamycin compl...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Feng, Daorong, Youn, Dou Yeon, Zhao, Xiaoping, Gao, Yanguang, Quinn, William J., Xiaoli, Alus M., Sun, Yan, Birnbaum, Morris J., Pessin, Jeffrey E., Yang, Fajun
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456374/
https://ncbi.nlm.nih.gov/pubmed/26042770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126240
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