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Discovery of New CDK8/CycC ligands with a Novel Virtual Screening Tool
Selective inhibition of Cyclin-dependent kinase 8 and cyclin C (CDK8/CycC) has been suggested as a promising strategy for reducing mitogenic signals in cancer cells with reduced toxic effects on normal cells. We developed a novel virtual screening protocol for drug development and applied it to disc...
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| 出版年: | ChemMedChem |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6428209/ https://ncbi.nlm.nih.gov/pubmed/30403831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800559 |
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