Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays

Androgen receptor (AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the conformational changes in AR that may affect the rec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genomics Proteomics Bioinformatics
Prif Awduron: Zhou, Wenfang, Duan, Mojie, Fu, Weitao, Pang, Jinping, Tang, Qin, Sun, Huiyong, Xu, Lei, Chang, Shan, Li, Dan, Hou, Tingjun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411960/
https://ncbi.nlm.nih.gov/pubmed/30639122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gpb.2018.03.007
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