Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and its Coactivator

Androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype maintenance and prostate cancer (PCa) development. The communications between the AR ligand-binding domain (LBD) and its coactivator are critical to the activation of AR. It is still unclear how the ligand b...

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Vydáno v:J Chem Inf Model
Hlavní autoři: Liu, Na, Zhou, Wenfang, Guo, Yue, Wang, Junmei, Fu, Weitao, Sun, Huiyong, Li, Dan, Duan, Mojie, Hou, Tingjun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110957/
https://ncbi.nlm.nih.gov/pubmed/29993249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.8b00283
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