Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells

One of the remarkable features of cancer cells is aerobic glycolysis, a phenomenon known as the “Warburg Effect”, in which cells rely preferentially on glycolysis instead of oxidative phosphorylation (OXPHOS) as the main energy source even in the presence of high oxygen tension. Cells with dysfuncti...

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Vydáno v:Oncotarget
Hlavní autoři: Li, Xiaoli, Han, Gaoyang, Li, Xiaoran, Kan, Quancheng, Fan, Zhirui, Li, Yaqing, Ji, Yasai, Zhao, Jing, Zhang, Mingzhi, Grigalavicius, Mantas, Berge, Viktor, Goscinski, Mariusz Adam, M. Nesland, Jahn, Suo, Zhenhe
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542273/
https://ncbi.nlm.nih.gov/pubmed/28624784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18199
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