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PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence
Alternative pathways of metabolism endowed cancer cells with metabolic stress. Inhibiting the related compensatory pathways might achieve synergistic anticancer results. This study demonstrated that pyruvate dehydrogenase E1α gene knockout (PDHA1 KO) resulted in alterations in tumor cell metabolism...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5288225/ https://ncbi.nlm.nih.gov/pubmed/27462778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10782 |
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