PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence

Alternative pathways of metabolism endowed cancer cells with metabolic stress. Inhibiting the related compensatory pathways might achieve synergistic anticancer results. This study demonstrated that pyruvate dehydrogenase E1α gene knockout (PDHA1 KO) resulted in alterations in tumor cell metabolism...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Li, Yaqing, Li, Xiaoran, Li, Xiaoli, Zhong, Yali, Ji, Yasai, Yu, Dandan, Zhang, Mingzhi, Wen, Jian-Guo, Zhang, Hongquan, Goscinski, Mariusz Adam, Nesland, Jahn M., Suo, Zhenhe
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288225/
https://ncbi.nlm.nih.gov/pubmed/27462778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10782
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