PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence

Alternative pathways of metabolism endowed cancer cells with metabolic stress. Inhibiting the related compensatory pathways might achieve synergistic anticancer results. This study demonstrated that pyruvate dehydrogenase E1α gene knockout (PDHA1 KO) resulted in alterations in tumor cell metabolism...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Li, Yaqing, Li, Xiaoran, Li, Xiaoli, Zhong, Yali, Ji, Yasai, Yu, Dandan, Zhang, Mingzhi, Wen, Jian-Guo, Zhang, Hongquan, Goscinski, Mariusz Adam, Nesland, Jahn M., Suo, Zhenhe
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288225/
https://ncbi.nlm.nih.gov/pubmed/27462778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10782
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