KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence In Cancer

Investigating therapeutic “outliers” that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in Kras(G12D) “knock-i...

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Gepubliceerd in:Cell
Hoofdauteurs: Burgess, Michael R., Hwang, Eugene, Mroue, Rana, Bielski, Craig M., Wandler, Anica M., Huang, Benjamin, Firestone, Ari J., Young, Amy, LaCap, Jennifer A., Crocker, Lisa, Asthana, Saurabh, Davis, Elizabeth M., Xu, Jin, Akagi, Keiko, Le Beau, Michelle M., Li, Qing, Haley, Ben, Stokoe, David, Sampath, Deepak, Taylor, Barry S., Evangelista, Marie, Shannon, Kevin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541948/
https://ncbi.nlm.nih.gov/pubmed/28215705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.020
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