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Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila

Gastric cancer development is strongly correlated with infection by Helicobacter pylori possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model, we show that CagA expression in the simple model epithelium of the larval wing imaginal disc causes dramatic tissue perturba...

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Bibliografiske detaljer
Main Authors: Wandler, Anica M., Guillemin, Karen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475654/
https://ncbi.nlm.nih.gov/pubmed/23093933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002939
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