KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence In Cancer

Investigating therapeutic “outliers” that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in Kras(G12D) “knock-i...

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Publicado no:Cell
Main Authors: Burgess, Michael R., Hwang, Eugene, Mroue, Rana, Bielski, Craig M., Wandler, Anica M., Huang, Benjamin, Firestone, Ari J., Young, Amy, LaCap, Jennifer A., Crocker, Lisa, Asthana, Saurabh, Davis, Elizabeth M., Xu, Jin, Akagi, Keiko, Le Beau, Michelle M., Li, Qing, Haley, Ben, Stokoe, David, Sampath, Deepak, Taylor, Barry S., Evangelista, Marie, Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541948/
https://ncbi.nlm.nih.gov/pubmed/28215705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.020
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