KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence In Cancer

Investigating therapeutic “outliers” that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in Kras(G12D) “knock-i...

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Publicat a:Cell
Autors principals: Burgess, Michael R., Hwang, Eugene, Mroue, Rana, Bielski, Craig M., Wandler, Anica M., Huang, Benjamin, Firestone, Ari J., Young, Amy, LaCap, Jennifer A., Crocker, Lisa, Asthana, Saurabh, Davis, Elizabeth M., Xu, Jin, Akagi, Keiko, Le Beau, Michelle M., Li, Qing, Haley, Ben, Stokoe, David, Sampath, Deepak, Taylor, Barry S., Evangelista, Marie, Shannon, Kevin
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541948/
https://ncbi.nlm.nih.gov/pubmed/28215705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.020
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