Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
The use of Cre/loxP recombination in mammalian cells has expanded rapidly. We describe here that Cre expression in cultured mammalian cells may result in a markedly reduced proliferation and that this effect is dependent on the endonuclease activity of Cre. Chromosome analysis after Cre expression r...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11481484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161269798 |
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