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Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
The use of Cre/loxP recombination in mammalian cells has expanded rapidly. We describe here that Cre expression in cultured mammalian cells may result in a markedly reduced proliferation and that this effect is dependent on the endonuclease activity of Cre. Chromosome analysis after Cre expression r...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55399/ https://ncbi.nlm.nih.gov/pubmed/11481484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161269798 |
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