Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

The use of Cre/loxP recombination in mammalian cells has expanded rapidly. We describe here that Cre expression in cultured mammalian cells may result in a markedly reduced proliferation and that this effect is dependent on the endonuclease activity of Cre. Chromosome analysis after Cre expression r...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Loonstra, Ate, Vooijs, Marc, Beverloo, H. Berna, Allak, Bushra Al, van Drunen, Ellen, Kanaar, Roland, Berns, Anton, Jonkers, Jos
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2001
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11481484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161269798
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