Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay
Missense mutations within the central DNA binding region of p53 are the most prevalent mutations found in human cancer. Numerous studies indicate that ‘hot-spot’ p53 mutants (which comprise ∼30% of human p53 gene mutations) are largely devoid of transcriptional activity. However, a growing body of e...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29741/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.5.e28 |
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