Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay

Missense mutations within the central DNA binding region of p53 are the most prevalent mutations found in human cancer. Numerous studies indicate that ‘hot-spot’ p53 mutants (which comprise ∼30% of human p53 gene mutations) are largely devoid of transcriptional activity. However, a growing body of e...

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Bibliografske podrobnosti
Main Authors: Kovvali, Gopala K., Mehta, Bena, Epstein, Charles B., Lutzker, Stuart G.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2001
Teme:
NAR Methods Online
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC29741/
https://ncbi.nlm.nih.gov/pubmed/11222779
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