Sugar additives for MALDI matrices improve signal allowing the smallest nucleotide change (A:T) in a DNA sequence to be resolved

Sample preparation for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) of DNA is critical for obtaining high quality mass spectra. Sample impurity, solvent content, substrate surface and environmental conditions (temperature and humidity) all affect the rate of matrix–anal...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Shahgholi, Mona, Garcia, Benjamin A., Chiu, Norman H. L., Heaney, Paul J., Tang, Kai
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2001
Assuntos:	NAR Methods Online
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60251/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.19.e91
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