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A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
Conditional gene inactivation using the Cre/loxP system is widely used, but the difficulty in properly regulating Cre expression remains one of the bottlenecks. One approach to regulate Cre activity utilizes a mutant estrogen hormone-binding domain (ER(T)) to keep Cre inactive unless the non-steroid...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083861/ https://ncbi.nlm.nih.gov/pubmed/11306549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve064 |
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