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Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites

The spatiotemporal manipulations of gene expression by the Cre recombinase (Cre) of bacteriophage P1 has become an essential asset to understanding mammalian genetics. Accumulating evidence suggests that Cre activity can, in addition to excising targeted loxP sites, induce cytotoxic effects, includi...

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Detaylı Bibliyografya
Asıl Yazarlar: Janbandhu, Vaibhao C, Moik, Daniel, Fässler, Reinhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956542/
https://ncbi.nlm.nih.gov/pubmed/24280829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27271
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