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Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites

The spatiotemporal manipulations of gene expression by the Cre recombinase (Cre) of bacteriophage P1 has become an essential asset to understanding mammalian genetics. Accumulating evidence suggests that Cre activity can, in addition to excising targeted loxP sites, induce cytotoxic effects, includi...

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Bibliographic Details
Main Authors: Janbandhu, Vaibhao C, Moik, Daniel, Fässler, Reinhard
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956542/
https://ncbi.nlm.nih.gov/pubmed/24280829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27271
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