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Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites
The spatiotemporal manipulations of gene expression by the Cre recombinase (Cre) of bacteriophage P1 has become an essential asset to understanding mammalian genetics. Accumulating evidence suggests that Cre activity can, in addition to excising targeted loxP sites, induce cytotoxic effects, includi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3956542/ https://ncbi.nlm.nih.gov/pubmed/24280829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27271 |
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