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Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten(LoxP/LoxP);Braf(CA/+) Mice

Current genetically-engineered mouse melanoma models are often based on Tyr::CreER(T2)-controlled MAPK pathway activation by the BRAF(V600E) mutation and PI3K pathway activation by loss of PTEN. The major drawback of these models is the occurrence of spontaneous tumors caused by leakiness of the Tyr...

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書目詳細資料
發表在:Int J Mol Sci
Main Authors: Deken, Marcel A., Song, Ji-Ying, Gadiot, Jules, Bins, Adriaan D., Kroon, Paula, Verbrugge, Inge, Blank, Christian U.
格式: Artigo
語言:Inglês
出版: MDPI 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187949/
https://ncbi.nlm.nih.gov/pubmed/27999416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17122149
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