Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten(LoxP/LoxP);Braf(CA/+) Mice

Current genetically-engineered mouse melanoma models are often based on Tyr::CreER(T2)-controlled MAPK pathway activation by the BRAF(V600E) mutation and PI3K pathway activation by loss of PTEN. The major drawback of these models is the occurrence of spontaneous tumors caused by leakiness of the Tyr...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Deken, Marcel A., Song, Ji-Ying, Gadiot, Jules, Bins, Adriaan D., Kroon, Paula, Verbrugge, Inge, Blank, Christian U.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187949/
https://ncbi.nlm.nih.gov/pubmed/27999416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17122149
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