Early-life febrile seizures worsen adult phenotypes in Scn1a mutants

Mutations in the voltage-gated sodium channel (VGSC) gene SCN1A, encoding the Na(v)1.1 channel, are responsible for a number of epilepsy disorders including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS). Patients with SCN1A mutations often experience prolonged early-li...

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Udgivet i:Exp Neurol
Main Authors: Dutton, Stacey B. B., Dutt, Karoni, Papale, Ligia A., Helmers, Sandra, Goldin, Alan L., Escayg, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538963/
https://ncbi.nlm.nih.gov/pubmed/28373025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2017.03.026
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