Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Na(v)1.1 VGSC α-subunit, underlie several forms of epilepsy, including Dravet syndrome (DS) and genetic epilepsy...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Dutton, Stacey B., Makinson, Christopher D., Papale, Ligia A., Shankar, Anupama, Balakrishnan, Bindu, Nakazawa, Kazu, Escayg, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740063/
https://ncbi.nlm.nih.gov/pubmed/22926190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.012
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker