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Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility
Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Na(v)1.1 VGSC α-subunit, underlie several forms of epilepsy, including Dravet syndrome (DS) and genetic epilepsy...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740063/ https://ncbi.nlm.nih.gov/pubmed/22926190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.012 |
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