Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility

Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Na(v)1.1 VGSC α-subunit, underlie several forms of epilepsy, including Dravet syndrome (DS) and genetic epilepsy...

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Autori principali: Dutton, Stacey B., Makinson, Christopher D., Papale, Ligia A., Shankar, Anupama, Balakrishnan, Bindu, Nakazawa, Kazu, Escayg, Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740063/
https://ncbi.nlm.nih.gov/pubmed/22926190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.012
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