Altered Function of the SCN1A Voltage-gated Sodium Channel Leads to γ-Aminobutyric Acid-ergic (GABAergic) Interneuron Abnormalities

Voltage-gated sodium channels are required for the initiation and propagation of action potentials. Mutations in the neuronal voltage-gated sodium channel SCN1A are associated with a growing number of disorders including generalized epilepsy with febrile seizures plus (GEFS+),(7) severe myoclonic ep...

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Главные авторы: Martin, Melinda S., Dutt, Karoni, Papale, Ligia A., Dubé, Céline M., Dutton, Stacey B., de Haan, Georgius, Shankar, Anupama, Tufik, Sergio, Meisler, Miriam H., Baram, Tallie Z., Goldin, Alan L., Escayg, Andrew
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Neurobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843231/
https://ncbi.nlm.nih.gov/pubmed/20100831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078568
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