A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation

Mutations in the voltage-gated sodium channel SCN1A are responsible for a number of seizure disorders including Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and Severe Myoclonic Epilepsy of Infancy (SMEI). To determine the effects of SCN1A mutations on channel function in vivo, we generat...

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Bibliografiset tiedot
Päätekijät: Tang, Bin, Dutt, Karoni, Papale, Ligia, Rusconi, Raffaella, Shankar, Anupama, Hunter, Jessica, Tufik, Sergio, Yu, Frank H., Catterall, William A., Mantegazza, Massimo, Goldin, Alan L., Escayg, Andrew
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735447/
https://ncbi.nlm.nih.gov/pubmed/19409490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.04.007
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